Research studies.   DHEA is a hormone produced by the adrenal glands, suggested as the starting material for both testosterone and estrogen. As a supplement, DHEA is made by a synthetic chemical process and is a hormone, not a nutrient. The Natural Pharmacist Encyclopedia (click Herbs & Supplements A-Z, then DHEA)reports several studies in which use of DHEA appeared to have some impact on sexual performance. A study of females with adrenal insufficiency reported improved sexual function during a 4-month treatment period. A study with both male and female participants with osteoporosis found improved libido in women over age 70. A study of males with erectile dysfunction showed significant improvement in function attributed to use DHEA.

Target Symptoms and Dosage.    In this context, the primary target is impaired sexual performance from hormone deficiency. There is large variance in the recommended dosage level with some suggesting as low as 5-15 mg per day and others suggesting typical therapeutic dosage of DHEA ranges from 50 to 200 mg daily.

Side Effects and Contraindications.   Although DHEA appears to be safe, there are reports of unwanted side effects, particularly at the higher dosage levels. There are reports that use may decrease levels of HDL ("good") cholesterol. Side effects reported have included acne and unwanted male pattern hair growth.

Summary.  Caution, as always, is always warranted in combining DHEA with prescribed medications. The prescribing physician should be involved in the decision to limit the risk of undesired interactions. Because of DHEA's hormonal involvement, it may have very different effects in men, premenopausal women, and postmenopausal women.